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Xing-Chen Liu

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Review Open access Sep 2026

The ubiquitin-editing enzyme A20 (TNFAIP3): mechanisms of activation, biological function, diseases and therapeutic targets

A20, encoded by tumor necrosis factor alpha-induced protein 3 (TNFAIP3), is a ubiquitin-editing enzyme that acts as a central regulator of inflammatory signal termination, immune homeostasis and tissue protection. By controlling receptor-proximal ubiquitin signaling, A20 limits the amplitude and duration of inflammator...

Jun-Ying Hu, Xing-Chen Liu, Wen-Qiao Zhou et al. · 0 citations

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