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Xing-Chun Gou

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Open access Sep 2026

Click chemistry ligation-initiated bisulfite-free assay on nanobeads for highly sensitive detection of site-specific 5 mC.

5-Methylcytosine (5 mC) represents the most prevalent and functionally significant DNA modification in mammalian genomes. Aberrations in its status are intricately associated with the pathogenesis of various diseases, including cancer and neurodegenerative disorders. The ultrasensitive detection of low-abundance 5 mC i...

Zhen-Hao Zhang, Shu-Han Lan, Bin Li et al. · 0 citations
Review Jul 2026

Innovative advances and clinical applications of cell-free DNA methylation detection technologies.

This review systematically examines the two major strategies: the ones based on bisulfite-dependent DNA modification and the bisulfite-free methods, including the techniques for whole-genome methylation profiling and methods targeting specific genomic regions.

Zhen-Hao Zhang, Luyao Zhu, Yiqian Ren et al. · 0 citations

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