Author

Xing-Guo Liu

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Review Open access Aug 2026

Mitochondrial DNA in Tumor Evolution and Heterogeneity: Characteristics, Technological Advances, Applications and Challenges

Tumor heterogeneity and Darwinian evolution act as core drivers of therapeutic resistance. Deciphering the phylogenetic architecture of cancer demands high‐resolution lineage tracing. Nevertheless, exogenously introduced lineage markers possess inherent limitations. This review presents somatic mitochondrial DNA (mtD...

Zifeng Ruan, Zi-Hao Chen, Wei-Chen Yu et al. · MedComm - Oncology · 0 citations

Review 2025

An exquisite symphony: protein post-translational modifications govern mitochondrial fate

Ten key PTMs, including lactylation, succinylation, succinylation, SUMOylation, and S-nitrosylation, acting on core regulators such as dynamin-related protein 1(DRP1), optic atrophy 1 (OPA1), Parkin, and mitochondrial Rho GTPase 1 (MIRO1) are summarized to provide a comprehensive resource for understanding mitochondria...

Haolin Ding, E. Taoxia, Jing-Cai He et al. · Element · 0 citations

Open access Jul 2026

Mitochondrial pearling is controlled by the inner membrane and mediates segregation of the luminal content and membrane scission.

This work uncovers the unique biophysical mechanism of mitochondrial pearling and its functional significance for organelle dynamics.

W. Iqbal, Ben Zucker, Xiao-Ying Liu et al. · Proceedings of the National... · 0 citations