Author

Xing Jia

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Review Open access Oct 2026

KRAS Mutations in Cancers: From Undruggable Dilemma to Precision Medicine

ABSTRACT KRAS is one of the most frequently altered oncogenic drivers across human solid tumors and has long represented a central challenge in precision oncology. The clinical success of covalent KRAS G12C inhibitors has transformed a historically “undruggable” target into a tractable therapeutic class, but durable be...

Jia-Ying Cai, Yi-Min Wu, Xing Jia et al. · MedComm · 0 citations

Open access Sep 2026

Paeoniflorigenone triggers TRIM28 phosphorylation-dependent ferroptosis and immune activation to suppress intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma is a highly lethal malignancy characterized by a rising incidence and a dismal 5-year survival rate of <10%. While targeted therapies and immunotherapies have expanded treatment paradigms, their clinical efficacy remains hampered by modest patient response rates. Here, we identify total...

Kai-Nan Lin, Yun-Kun Lu, Zhi-Hao Lin et al. · Pharmacological Research · 0 citations