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Xing-Pin Wei

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Sep 2026

Stereodivergent Construction of Adjacent Tetrasubstituted Stereocenters Enabled by CPA-Catalyzed Enantioselective Desymmetric Friedel-Crafts Reaction of α-Aryl-α-fluoro-1,3-indanediones.

Here we report the asymmetric Friedel-Crafts reaction between compounds α-aryl-α-fluoro-1,3-indanediones and indoles, catalyzed by an efficient chiral phosphoric acid catalyst. Using this methodology, a series of cyclic β-fluoroalcohols bearing two adjacent chiral centers were synthesized in up to 95% yield, with excel...

Xing-Pin Wei, Dan Li, Fen Gao et al. · 0 citations

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