Honokiol ameliorates pyroptosis in bovine mammary epithelial cells via SIRT3-mediated inhibition of the NLRP3 inflammasome.
Bovine mastitis causes significant economic losses in the dairy industry, with excessive inflammation and pyroptosis in its pathogenesis. Honokiol (HKL), a natural compound that may regulate mitochondrial deacetylase Sirtuin 3 (SIRT3)-related signaling, possesses anti-inflammatory properties. This study aimed to invest...