Efficient intracellular delivery of neoantigen-encoded mRNAs is central to the development of effective cancer vaccines and immunotherapies. However, how the nanoscale geometry of delivery carriers impacts mRNA delivery remains poorly understood, largely because conventional delivery platforms do not readily permit sys...
Meng-Xi Zheng, A. Dwivedy, Dhanush Gandavadi et al.· bioRxiv· 0 citations
Biological processes are often regulated through reactions involving supramolecular protein complexes organized with nanoscale precision, such as the apoptosome that activates procaspase-9 through defined stoichiometry to induce apoptosis. Here we report designer CASCAD (CARD Assembly on SCAffold DNA), a self-assembled...
Dhanush Gandavadi, A. Dwivedy, Revathi Manoharaan et al.· bioRxiv· 0 citations
With continued advances in structural design, ligand functionalization, and immune engineering, DNA nanotechnology holds the potential to reshape cancer immunotherapy and pave the way for highly targeted, personalized, and effective treatments that outperform current clinical approaches in specificity, efficacy, and sa...
