Open access
Sep 2026
Nickel-Catalyzed de novo Synthesis of C─N Atropisomeric Biaryls via Dual Chelation-Assisted Aza-Michael Addition.
The asymmetric construction of C─N bonds using readily available C─H (arene) and N─H (amine) reagents constitutes a modular and flexible synthetic strategy. Nevertheless, de novo synthesis of axially chiral C─N scaffolds via direct C─H/N─H coupling remains a formidable challenge, and it has been previously restricted t...
Xiao-Han Zhu, Yue Shi, Wei Wang et al.
· Angewandte Chemie · 1 citation