Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation and progressive joint destruction, and approximately 30-40% of patients respond inadequately to currently available disease-modifying antirheumatic drugs. Growing evidence suggests that immune abnormalities driving joint inflammation may arise...
Abstract Osteoporosis (OP) and osteoarthritis (OA) are two prevalent age-related musculoskeletal disorders that frequently coexist in elderly populations, substantially complicating clinical diagnosis and treatment. In recent years, flavonoid active compounds have attracted increasing research interest for OP-OA comorb...
Xing-Wen Xie, Yan-Dong Liu, Yan-Jun Zhang et al.· Drug Design, Development and...· 0 citations
Postmenopausal osteoporosis(PMOP)is a common metabolic bone disease characterized by an imbalance in bone remodeling due to estrogen deficiency. Increasing evidence suggests that alterations in gut microbiota, intestinal barrier, immune response, microbial metabolites, and autonomic nervous activity are involved in pos...
Yang-Yang Chen, Ding-Peng Li, Zhong Wang et al.· Frontiers in Immunology· 0 citations
A four-tier mechanistic framework of Bifidobacterium-mediated regulation of osteoporosis is established in which the evidence is stratified into three categories—direct evidence from Bifidobacterium-specific studies, indirect evidence from other probiotics, and general mechanisms of gut microbiota-regulated bone metabo...
