Open access
Jul 2026
AMPKγ2 Deacetylation Drives Nuclear Translocation and Doxorubicin-Induced Cardiomyopathy via Nucleolar Stress Signaling
It is reported that Dox induces isoform-specific deacetylation and nuclear accumulation of γ2, triggering nucleolar stress and p53-mediated apoptosis and suggested a promising cardio-oncology strategy that combines HDAC inhibitors with Dox to mitigate DIC.
Canrong Li, Tiantian Yi, Yuting Cui et al.
· bioRxiv · 0 citations