Author

Xinhua Song

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Open access Sep 2026

Piper nigrum L. and its main component piperine ameliorate hyperuricemia and hyperuricemia-related renal inflammation through suppressing the JAK2-STAT3-XDH/SOCS3/TNF-α signalling pathway

Hyperuricemia is a metabolic disease characterized by serum uric acid (UA) levels remaining above normal levels for a long period of time, which has become a huge challenge faced by society. The fruits of P. nigrum L. (P. nigrum) as traditional Indian medicine was used to treat various diseases. However, the anti-h...

Nan-Chuan Li, Meiling Xin, Xin-Hua Song et al. · Food & Medicine Homology · 0 citations

Open access Sep 2026

CIPK11 Regulates Plant Adaptation to Nitrate Availability in Arabidopsis

Nitrate (NO3−) is an essential nitrogen source and an important signaling molecule that regulates plant growth and development in response to nitrogen availability. Although several CBL-interacting protein kinases (CIPKs) have been implicated in nitrate signaling, the role of CIPK11 (PKS5) in nitrate availability respo...

Hai-Jing Wang, Tong-Tong Liu, Hong-Zhi Xu et al. · Plants · 0 citations

Open access Aug 2026

Inhibition of Xanthine Oxidase by Dietary Flavonoids: SWISS-MODEL-Based Docking, In Vitro Analysis, In Vivo Structure-Activity Investigations and Gut Microbiota-Based Systematic Toxicological Evaluation

Hyperuricemia (HUA), a prevalent metabolic disorder, needs new xanthine oxidase (XOD) inhibitor studies to reduce severe side effects. In this study, the inhibitory activities of 20 dietary flavonoids against XOD were determined in vitro, and a structure-activity relationship (SAR) model was subsequently developed....

Pingping Guo, Xing-Xing Liu, Feng-Ying Dong et al. · Food Science and Human Welln... · 0 citations