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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Xinran Ding

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Review Aug 2026

Targeting macrophage mitochondrial metabolism in tuberculosis: from pathogen-driven biochemical reprogramming to host-directed pharmacotherapy.

Mycobacterium tuberculosis (Mtb) remains a leading global health threat. The fate of the Mtb-infected macrophage is critically governed by host mitochondrial metabolism. In this review, we propose a unifying biochemical "threshold model" of tuberculosis pathogenesis: Mtb functions as an intracellular "mitochondrial par...

Jianhao Xu, Xinran Ding, Jia-Hui Tang et al. · 0 citations

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