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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Xinran Gao

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Aug 2026

A hippocampal-lateral posterior thalamic nucleus neural circuit mediates cognitive impairment and metabolic dysfunction in male mice with type 2 diabetes.

OBJECTIVES Type 2 diabetes mellitus (T2DM) is a multisystem disorder characterized by metabolic dysregulation and cognitive decline. While hippocampal dysfunction is a recognized feature of cognitive impairment, upstream neural circuits that couple peripheral metabolic signals to central cognition remain poorly defined...

Huai-Zhi Sun, Xinran Gao, Quantong Xu et al. · 0 citations
Open access Jul 2026

Calycosin attenuates LPS-induced microglia inflammatory responses and microglia-mediated synaptic impairment via modulation of TLR4/MyD88/NF-κB signaling pathway

Caly could exert potential effects on suppressing LPS-induced microglia activation and inflammatory responses in immortalized BV2 cells by regulating TLR4/MyD88/NF-κB signaling pathway, and attenuating microglia-mediated neuronal injury and synaptic impairment in immortalized HT-22 cells.

Xinran Gao, Ruiyang Wang, Hejuntao Chen et al. · 0 citations

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