Review
Open access
Jul 2026
Hippocampal Remodeling in Chronic Pain: Structural, Functional, Cellular, Metabolic, and Molecular Mechanisms and Therapeutic Perspectives.
This review systematically synthesizes current evidence on hippocampal alterations in chronic pain across multiple levels and proposes a multiscale integrative framework in which synaptic imbalance, neuroimmune activation, and neurotrophic dysregulation interact to drive hippocampal dysfunction, forming a bidirectional loop that links pain, emotion, and cognition.
Zhang Yanan, Xiangxin Xing, Chen Wenyu et al.
· Pharmacological Research · 0 citations