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Xinyao Xiang

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Open access Aug 2026

GDP-Loaded K‑Ras Transiently Binds to Effector B‑Raf RBD, Mirroring the Structure of the Active GTP-Loaded Complex

The Ras-Raf protein association initiates the downstream mitogen-activated protein kinase (MAPK) signaling cascade. This interaction depends on the Ras-nucleotide ligand, whereby Raf preferentially binds to the active guanosine triphosphate (GTP)-loaded state over the guanosine diphosphate (GDP)-loaded state of Ras. Wh...

Xinyao Xiang, Mamata Basnet, C. Yuan et al. · 0 citations

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