GDP-Loaded K‑Ras Transiently Binds to Effector B‑Raf RBD, Mirroring the Structure of the Active GTP-Loaded Complex
The Ras-Raf protein association initiates the downstream mitogen-activated protein kinase (MAPK) signaling cascade. This interaction depends on the Ras-nucleotide ligand, whereby Raf preferentially binds to the active guanosine triphosphate (GTP)-loaded state over the guanosine diphosphate (GDP)-loaded state of Ras. Wh...