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Author

Xinye Ni

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Open access Oct 2026

HSP90AA1 induces M2 macrophage polarization via stabilizing ITGB1 and promoting CCL2 secretion in nasopharyngeal carcinoma

In vitro models and retrospective clinical correlation suggest that the HSP90AA1-ITGB1-CCL2 axis may drive immunosuppressive TME remodeling in NPC, highlighting HSP90AA1 as a promising predictive biomarker and therapeutic target against immunotherapy resistance.

Ming-Jun Ding, Chun-Sheng Wang, Xiang Cao et al. · 0 citations
Open access Jul 2026

ProtSyntax: a protein large language model for decoding post-translational modification syntax and function

ProtSyntax is introduced, a PTM-aware foundation protein language model combining protein-aware positional encoding, bidirectional state-space propagation, geometry-constrained attention and adaptive multi-objective learning that has the potential to decode the regulatory language of the modified proteome.

Yiyu Lin, Jiahui Wu, You Zhou et al. · 0 citations

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