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Sep 2026

Quercetin protects against murine cytomegalovirus-induced pneumonia via suppression of viral replication and NLRP3 inflammasome activation.

Cytomegalovirus (CMV)-induced pneumonia is associated with excessive pulmonary inflammation and severe lung injury, particularly in immunocompromised individuals. Effective therapeutic strategies targeting both viral replication and inflammation-driven lung damage remain limited. Quercetin, a naturally occurring flavon...

Ping Sun, Xin-Xiang Chen, Xiao-Juan Wang et al. · 0 citations
Aug 2026

Vilazodone inhibits NLRP3 inflammasome assembly by targeting the NACHT domain and alleviates inflammatory disease.

The NLRP3 inflammasome plays a central role in innate immunity and inflammatory diseases, yet effective inhibitors remain limited. Here, we identified vilazodone, an FDA-approved antidepressant, as a potent inhibitor of NLRP3 inflammasome activation by small-molecule screening. Vilazodone significantly suppressed IL-1β...

Xiang-Yu Yang, Gui-Fang Xiong, Jie Yang et al. · 0 citations

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