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Open access Jul 2026

Attribution of PM2.5-Induced Transcriptomic Perturbation to Toxic Components.

Ambient fine particulate matter (PM2.5) is a chemically complex mixture whose health impacts are not fully captured by particle mass. Here, we developed an interpretable chemotranscriptomic framework to attribute PM2.5-induced molecular perturbations to toxicity-relevant components. PM2.5 collected from urban roadside...

Shihao Wang, Xinyu Li, Yong Han et al. · 0 citations
Open access Jul 2026

DEHP exposure induces cholesterol dysregulation and inflammatory signaling in human colonic epithelial cells: Implications for early colorectal carcinogenesis.

It is suggested that short-term DEHP exposure may disrupt intestinal epithelial homeostasis through a mechanism involving cholesterol transport impairment (SREBF1/ABCA1/ABCG1 axis), representing an early event in DEHP-associated colorectal pathogenesis.

Xinrui Zhou, Jiayi Diao, Jia-Min Lu et al. · 0 citations

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