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Oct 2026

p62-Keap1-Nrf2 positive feedback loop protects against inorganic arsenic-induced senescence and EMT in alveolar type II cells.

Inorganic arsenic (As) exposure is known to induce pulmonary fibrosis, yet the underlying mechanisms remain incompletely understood. This study investigated the crosstalk between sequestosome 1 (SQSTM1/p62) and nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating cellular senescence and epithelial-mesenchym...

Xin-Yang Guo, Xin-Yu Ma, Li-Yi Qin et al. · 0 citations
Open access Aug 2026

Tailoring Crystallization Modulators for the Facile Synthesis of One-Dimensional Covalent Organic Frameworks to Boost Ultrasound-Triggered Pyroptosis and Immunotherapy.

Ultrasound (US)-induced tumor cell pyroptosis holds great potential for cancer immunotherapy; however, its efficacy is often constrained by the inadequate reactive oxygen species (ROS) generation of conventional sonosensitizers. Herein, one-dimensional porphyrin-based covalent organic frameworks (designated as TD-anili...

Ji-Wei Wang, Sainan Liu, Zhendong Liu et al. · 0 citations

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