The eye is increasingly recognized as a tissue shaped by systemic immune and metabolic states rather than an isolated immune-privileged organ. Translocator protein (TSPO), an 18-kDa outer mitochondrial membrane protein enriched in myeloid and glial cells, links mitochondrial homeostasis, redox signaling, lipid metaboli...
Zu-Yi Yang, Xin-Yi Zhang, Dian-Zhe Tian et al.· Frontiers in Immunology· 0 citations
Abstract Polypoidal choroidal vasculopathy (PCV) is a distinct variant of neovascular age‐related macular degeneration (AMD) and a major cause of vision loss in older adults, yet its pathogenesis remains poorly understood. Pachychoroid PCV is a subtype characterized by poor treatment response, minimal typical AMD featu...
It is suggested that the effectiveness of mRNA cancer vaccines depends not only on selecting the right antigens but also on delivery methods that modulate the immune response and reshape the tumor microenvironment.
Dianzhe Tian, Xin-Shi Li, Zuyi Yang et al.· Frontiers in Pharmacology· 0 citations
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