Xiu-Cheng Yang

Integrated single-cell TCR analysis across tissue identifies GZMK+CD8+ T cells promoting fibrosis via TGF-β signalling in IPF

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with progressive scarring and an unknown aetiology, but the cross-tissue immune network remains poorly understood. Here, we performed paired single-cell RNA sequencing and T cell receptor profiling of lung, mediastinal lymph node, and peripheral b...