Author

Xiuli Liu

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Open access Oct 2026

Single-nucleus transcriptomics uncovers region-specific molecular features underlying selective aging vulnerability of cholinergic neurons

Summary Cholinergic neurons exhibit functional and molecular heterogeneity across the basal forebrain (BF), midbrain (MB), and brainstem (BS), while the aging-associated transcriptional features remain poorly characterized. Here, we performed single nucleus RNA sequencing (snRNA-seq) on 108,062 nuclei from the MS/VDB,...

Qian-Qian Li, Jia-Le Chen, Xiu-Li Liu et al. · iScience · 0 citations

#artificial intelligence Preprint Sep 2026

StainPresetNet: Stain Preset Network for Fast Multi-to-Multi Stain Normalization

This work proposes StainPresetNet - a novel framework that combines structural preservation with dataset-level color mapping while maintaining computational efficiency, and implements pixel-wise normalization guided by preset reference images, enabling multi-directional adaptability without retraining.

Hongtao Kang, Die Luo, Li Chen et al. · 0 citations