Enhanced Synaptic-Related Transcriptional Programs in Human Forebrain Organoids for Modeling Synaptopathy-Associated Neurodevelopmental Disorders
Human cerebral organoids (COs) are well-recognized in vitro models for recapitulating human fetal brain development. However, spontaneous unguided differentiation of COs leads to severe regional heterogeneity, limiting standardized research and high-throughput drug screening. In this study, we generated optimized human...