Open access
Jul 2026
Structural basis of cooperative neutralization of the PldB toxin by immunity proteins in Pseudomonas aeruginosa.
PldB, a type VI secretion system-dependent phospholipase D (PLD) effector secreted by multidrug-resistant Pseudomonas aeruginosa, alters host cell membrane permeability and facilitates pathogen internalization. Its cytotoxic activity is neutralized by three cognate immunity proteins-PA5086, PA5087, and PA5088-which pro...
Xiaoyun Yang, Jiawen Yang, Hong Wang et al.
· Communications Biology · 0 citations