Abstract 8972: Discovery and Temporal Validation of Proteomic Signatures for Incident Chronic Limb-Threatening Ischemia in the Atherosclerotic Risk in Communities (ARIC) Study
Background: Chronic limb-threatening ischemia (CLTI), a severe form of peripheral artery disease (PAD) with rest pain, non-healing ulcers, or gangrene, is a devastating condition with high risks of limb loss and mortality. Emerging evidence indicates that CLTI reflects a distinct pathophysiologic state rather than s...