Author

Xi-Xian Chen

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Book Open access Aug 2026

From Structure to Function: Preference Alignment for Function-aware Protein Inverse Folding

A function-aware preference alignment framework that improves functional preservation by fine-tuning models to favor function-preserving sequences over function-disrupting alternatives, avoiding the need for explicit function optimization.

Nilufer Tamatgar, Soobin Park, Ying-Hua Yao et al. · Proceedings of the 32nd ACM... · 0 citations

Book Open access Aug 2026

From Structure to Function: Preference Alignment for Function-aware Protein Inverse Folding

Protein inverse folding models conditioned on structure achieve high sequence recovery but often fail to preserve biological function due to the lack of functional supervision. We propose a function-aware preference alignment framework that improves functional preservation by fine-tuning models to favor function-preser...

Nilufer Tamatgar, Soobin Park, Yinghua Yao et al. · Proceedings of the 32nd ACM... · 0 citations