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Author

Xu-Cong Teng

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Open access Sep 2026

Identification of a G-quadruplex-forming cell-free DNA fragment as a biomarker for the precise diagnosis of hepatocellular carcinoma

Early detection of hepatocellular carcinoma (HCC) remains challenging, as the currently recommended surveillance strategy based on ultrasound combined with alpha-fetoprotein (AFP) is limited by suboptimal sensitivity and accessibility. Cell-free DNA (cfDNA) provides a minimally invasive avenue for cancer detection. How...

Jian-Zhe Sun, Xu-Cong Teng, Wei-Zhi Zhang et al. · 0 citations
Review Sep 2026

Expanding the E3 Ligase Landscape: From Small Molecule to Biological Targeted Protein Degradation.

This review summarizes the development of classical small-molecule E3 ligase ligands and highlights emerging biological recruitment strategies involving antibodies, nanobodies, aptamers, peptides, and engineered proteins that provide greater programmability and selectivity.

Xuan Zhao, Yu-Han Liu, Xu-Cong Teng · 0 citations
Open access Aug 2026

Single-Cell Imaging of Site-Specific RNA-Protein Interactions.

Using RAPID, it is found that SFPQ-NEAT1 interactions exhibited distinct spatial organization and dynamic changes upon cellular stimulation, indicating that the SFPQ-NEAT1 axis is closely associated with nuclear reorganization and stimulus-responsive gene regulation.

Yuncong Wu, Qiu-Shuang Zhang, Yi-Cong Dai et al. · 0 citations

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