Author

Xu-Lin Liu

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Open access Oct 2026

Sex‐specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia

Abstract INTRODUCTION Sex differences exist in Alzheimer's disease (AD) treatment response, but the role of sex in disease development and progression remains unclear. METHODS We performed multimodal analyses of AD biomarker–positive individuals with mild cognitive impairment (MCI) and AD from the Alzheimer's Disease N...

Xu-Lin Liu, S. D. de Boer, M. Tartaglia · Alzheimer's & Dementia · 0 citations

Review Open access Oct 2026

Dynamic remodeling of microglial responses in Alzheimer’s disease: heterogeneous states, spatiotemporal progression, and immunometabolic dysregulation

Alzheimer’s disease (AD) is characterized by progressive neuroinflammation involving microglia whose functional responses extend far beyond the classical M1/M2 framework and form a dynamically heterogeneous continuum. Here, we review recurrent disease-associated microglia (DAM) states and transcriptional programs, incl...

Si-Min Han, Shan-Shan Wang, Jing-Jing Liu et al. · Frontiers in Cell and Develo... · 0 citations