RAD51D deficiency enhances IFN-JAK-STAT signaling to upregulate PD-L1 and increase sensitivity to PD-L1 blockade in colorectal cancer
Homologous recombination (HR) repair deficiency is an important source of genomic instability in cancer and has increasingly been linked to tumor-immune interactions. However, the role of HR repair components in regulating immune checkpoint expression remains poorly defined in colorectal cancer (CRC). Here, we repo...