Discovery and characterization of Chondroitinase A with specificity for 4-O-sulfated N-acetylgalactosamine in Chondroitin sulfate/Dermatan sulfate.
Chondroitin sulfate (CS) and dermatan sulfate (DS) are glycosaminoglycans whose diverse biological functions are largely determined by specific sulfation patterns. The GlcA/IdoA-GalNAc4S (A/iA unit), where GlcA, IdoA, GalNAc and 4S denote D-glucuronic acid, L-iduronic acid, N-acetylgalactosamine and 4-O-sulfation, resp...