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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Xu Wang

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Oct 2026

Design and discovery of highly potent lysine 27 of histone H3 (H3K27) demethylase inhibitors for the treatment of inflammatory bowel disease.

Lysine specific demethylase 6A/B (KDM6A/B), histone lysine demethylases targeting H3K27me3, have emerged as key regulators of inflammatory gene expression and are increasingly implicated in the pathogenesis of inflammatory bowel disease (IBD). However, there remains a critical need for potent, selective, and cell-activ...

Yu-Qi Tang, Xin Hu, An-Cheng Shen et al. · 0 citations
Review Open access Oct 2026

Metabolic reprogramming in cancer-associated fibroblasts: orchestrating the tumor immune microenvironment and response to immune checkpoint blockade

Immune checkpoint blockade (ICB) has reshaped the therapeutic landscape of solid tumors. However, durable clinical benefit remains limited to a subset of patients because of primary or acquired resistance. Beyond tumor-intrinsic factors, the tumor microenvironment (TME) plays a critical role in shaping responsiveness t...

Luo-Man Gan, Zhong-Long Liu, Li-Ren Cao et al. · 0 citations
Open access Aug 2026

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

KDM6A phosphorylation is identified as a druggable epigenetic-immune checkpoint and mRNA-based modulation of enzyme post-translational status as a transformative paradigm to potentiate ICB in HNSCC is established.

Yi-Kang Ji, Xin-Ran Zhao, Cheng Hu et al. · 0 citations

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