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Review Sep 2026

Pyridones and macrocyclic pyrrolidones from marine fungal PKS-NRPS hybrids: biosynthetic origin, bioactivities, and synthetic advances.

Covering: 2002-2025Marine fungi have emerged as a prolific source of structurally unprecedented and biologically potent secondary metabolites, and hybrid polyketide synthase-non-ribosomal peptide synthase (PKS-NRPS) enzymes mainly from marine fungi like symbiotic Aspergillus and deep-sea Penicillium, represent an excep...

Ning Gao, F. Owusu, Jie Yu et al. · 0 citations
Sep 2026

Function-oriented synthesis of marine phidianidine derivatives as potent anti-MRSA agents.

Mechanistic study showed that 24a effectively inhibits biofilm formation and exerts its antibacterial effect by disrupting the bacterial cell membrane, paving the way for new strategies to combat antimicrobial resistance.

Qiong Wu, Bing-Yuan Yan, Chen Qu et al. · 0 citations

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