Review
Open access
Sep 2026
Context-dependent roles of the NLRP3 inflammasome in osteomyelitis and strategies for precision modulation
It is proposed that future NLRP3-targeted therapy for osteomyelitis should shift from “non-specific anti-inflammation” to “bone immune reprogramming”—stratified intervention based on infection stage, cell type, and inflammasome activation level, integrating NLRP3 modulation with antibacterial, anti-biofilm, anti-pyropt...
Li-Dan Yang, Lin Zhang, Xu-Xu Yang et al.
· Frontiers in Immunology · 0 citations