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Author

Xu-Yu Zhou

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Open access Sep 2026

ANKRD11 deficiency reprograms CD8+ T cell differentiation to enhance immunity in chronic infection and cancer

The identification of a T cell receptor targeting a clinically relevant HBV epitope and ANKRD11 as a key epigenetic regulator of CD8+ T cell dysfunction in chronic infection and tumors position ANKRD11 as a promising immunotherapy target for chronic HBV infection and cancer.

Wei Xu, Jie Guo, Xue Cao et al. · 0 citations
Open access Aug 2026

H3.3 chaperone Hira primes the effector program and function of regulatory T cells

It is shown that the histone variant H3.3 is enriched in tissue Tregs compared to splenic Tregs and its chaperone Hira is a critical regulator of Treg effector program, revealing a previously unreported epigenetic mechanism critical for Treg effector differentiation and function.

Xiang-Xiang Cao, Meng-Jie Lv, Zhi-Han Lv et al. · 0 citations

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