ABSTRACT
Fibrosis is a common end-stage pathological process in many chronic diseases and is characterized by excessive extracellular matrix (ECM) deposition and progressive tissue dysfunction. Effective antifibrotic therapies remain limited, and macrophages are increasingly recognized as key regulators of fibrogenesis...
Qing Bi, Ji-Chen Wang, Dong-Min Lai et al.· Chinese Medical Journal· 0 citations
Acute kidney injury (AKI) and its progression to chronic kidney disease (CKD) remain major unmet clinical challenges for which effective therapies are lacking. Although sensory neurons are recognized as key regulators of tissue injury and repair via neuroimmune crosstalk, their organization and function within the kidn...
Lei Wang, Huai-Kang Li, Ji Feng et al.· Cell Research· 0 citations
A previously unrecognized KLF4–SLC25A4 regulatory axis that contributes to ferroptosis and therapeutic response is uncovered, offering a potential strategy to improve sunitinib sensitivity in ccRCC.