Xu Zhang

Dual molecular and clinical machine-learning prognostic modeling in pancreatic ductal adenocarcinoma: a chaperone-mediated autophagy–based framework integrating multi-cohort molecular signatures and a single-center clinical nomogram

This study identified CMA-related cellular heterogeneity, established a molecular prognostic model that retained prognostic discrimination in two independent validation cohorts, demonstrated the functional relevance of KRT19, and developed an independent clinical prediction tool.