Ethyl caffeate alleviates NAFLD by modulating JNK/IRS-1/AKT signaling and the gut microbiota.
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide, yet no specific pharmacotherapy has been approved. Ethyl caffeate (EC), a natural phenolic compound with anti-inflammatory and antioxidant properties, has been suggested as a potential hepatoprotective agent, but its effica...