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Review Open access Jul 2026

Microbiota–innate immune crosstalk drives atherosclerosis: mechanisms, disease progression, and emerging therapeutic strategies

Atherosclerosis (AS) is a complex cardiovascular disease driven by the interplay of dysregulated lipid metabolism, chronic inflammation, and immune dysfunction. Increasing evidence has revealed that the gut microbiota not only regulates host metabolic homeostasis but also actively contributes to the initiation and prog...

Yongang Li, Jinheng Zhu, Mingkui Huang et al. · 0 citations
Open access Sep 2026

Preclinical evaluation of AL-001, a gene therapy for wet age-related macular degeneration

Suprachoroidal administration of AL-001 is well tolerated and provides durable, targeted aflibercept expression with pronounced antiangiogenic efficacy, and these results support AL-001 as a promising, long-acting therapeutic candidate for wAMD.

Xuan Liu, Hai-Yan Liu, Lei Wang et al. · 0 citations

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