USP16 promotes osteosarcoma progression by stabilizing ESRRA to enhance mitochondrial oxidative phosphorylation.
Osteosarcoma is a highly aggressive primary bone malignancy, yet the underlying mechanisms driving its metabolic reprogramming remain incompletely understood. In this study, we identified ubiquitin-specific protease 16 (USP16) as a critical oncogenic driver in osteosarcoma. Bioinformatics analysis showed that USP16 was...