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Xuan Wu

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Open access Aug 2026

In vivo labeling–based proteomic analysis of early follicle oocytes and cisplatin-induced alterations in mice

A systematic proteomic profile of oocytes from early-stage follicles, particularly primordial follicles, is critical to protect female reproductive capacity in the context of chemotherapy, yet progress has been hindered by the rarity of oocyte samples and technical challenges associated with oocyte isolation. In this s...

Zhi-Yan Jiang, Mei-Yu Bi, Xuan Wu et al. · 0 citations
Open access Aug 2026

Maternal PAN2 selectively maintains mRNA Poly(A) tail homeostasis to regulate RNA degradation during oocyte-to-early embryo transition in mice.

This study establishes maternal PAN2 as a critical regulator of poly(A) tail homeostasis, ensuring timely maternal mRNA clearance and proper ZGA, highlighting the stage-specific and tail-composition-dependent functions of the deadenylase cascade during the maternal-to-zygotic transition.

Xuan Wu, Hua Zhang, Yu-Ke Wu et al. · 0 citations

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