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Xuan Zhao

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Review Sep 2026

Expanding the E3 Ligase Landscape: From Small Molecule to Biological Targeted Protein Degradation.

This review summarizes the development of classical small-molecule E3 ligase ligands and highlights emerging biological recruitment strategies involving antibodies, nanobodies, aptamers, peptides, and engineered proteins that provide greater programmability and selectivity.

Xuan Zhao, Yu-Han Liu, Xu-Cong Teng · 0 citations

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