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Oct 2026

Mitochondria-Targeted Prodrug Nanoassemblies Elicit Antitumor Immunity via Mitophagy-Boosted Ferroptosis in Triple-Negative Breast Cancer

Ferroptosis, an immunogenic iron-dependent cell death driven by lipid peroxidation, holds promise for treating triple-negative breast cancer (TNBC). However, its efficacy is severely compromised by restricted iron availability and the potent GPX4/GSH defense system. Herein, we developed a mitochondria-targeted prodru...

Nian Liu, Qian Lin, Min Jiang et al. · 0 citations
Open access Aug 2026

The tumor suppressor menin is a key scaffold mediator for homologous recombination repair

It is reported that the scaffold protein menin, encoded by the Men1 gene, plays a crucial bridging role in H3K36-mediated HR repair, validating that menin governs HR repair in an H3K36me3-dependent manner.

Aobo Lian, Xing-Wen Zhu, B. Jin et al. · 0 citations

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