Aug 2026
Digestion of perineuronal nets in the ventral CA1 suppresses methamphetamine-induced conditioned place preference acquisition by modulating PV interneuron activity in female mice.
Findings indicate that MA-induced increased PNNs in the vCA1 promote the formation of CPP memory by regulating PV interneuron activity and suggests that targeting vCA1 PNNs and PV interneurons may represent a potential therapeutic strategy for MA addiction.
Jiayu Yao, Xing-Yu Wu, Zi-Rui Guo et al.
· Neuropharmacology · 0 citations