Xudong Guo

NLRP3 inflammasome in acute kidney injury: molecular mechanisms, post-translational regulation, and immunotherapeutic potential

Acute kidney injury (AKI) is a critical clinical syndrome characterized by a rapid decline in renal function. Dysregulated inflammatory responses play a crucial role in its pathogenesis, contributing to high patient mortality and a tendency to progress to chronic kidney disease (CKD). As a crucial sensor of the innate...