Open access
Aug 2026
Structure and mechanism of human sphingosine-1-phosphate transporter MFSD2B
Sphingosine-1-phosphate (S1P) is an essential signaling lipid that maintains vascular integrity and regulates immune cell trafficking. The major facilitator superfamily domain–containing protein 2B (MFSD2B) serves as the main S1P exporter in red blood cells and platelets; however, its structure and transport mechanism...
Shahbaz Ahmed, Ming-Kong Huang, Ya-Xin Dai et al.
· Nature Communications · 1 citation