Open access
Oct 2026
Acid-responsive nanoparticles with microneedles for anti‑inflammatory sonodynamic therapy of gouty arthritis
Abstract The pathological microenvironment of acute gouty arthritis (AGA) features local tissue acidification and the release of a storm of pro-inflammatory cytokines. To address this dual challenge, we engineered an acid-responsive curcumin-loaded nanoparticles microneedle system (Cur-PNPs@MN) that delivers curcumin w...
Jia-Qi Weng, Li-Li Feng, Bing-Hui Xie et al.
· Drug Delivery · 0 citations