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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Xue-Feng Wang

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Open access Aug 2026

IFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma

Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but many patients with large B cell lymphoma (LBCL) experience primary resistance or relapse. To uncover resistance mechanisms, here we examine pre-infusion tumor biopsies and observe that increased immunoregulatory macrop...

SaeBom Lee, A. Pavy, Nolan J. Beatty et al. · 0 citations

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