MBD3 Knockdown Promotes the Differentiation of Bovine iPSCs into Primordial Germ Cell-like Cells Associated with Altered Bivalent Modification of TGF-β-Related Genes
MBD3 knockdown during bovine iPSC reprogramming significantly enhances the differentiation efficiency of primordial germ cell-like cells (PGCLCs) under a 2D monolayer culture system, providing a mechanistic basis for optimizing bovine iPSC-derived PGCLC protocols through targeted epigenetic modulation.