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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Xue-Ling Wang

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Open access Oct 2026

CCNE1 overexpression drives a cGAS–STING-dependent interferon response and sensitizes HRD-positive ovarian cancer to immune checkpoint blockade

Abstract Background Homologous recombination deficiency (HRD) in high-grade serous ovarian carcinoma (HGSOC) canonically dictates sensitivity to platinum chemotherapy and poly(ADP-ribose) polymerase inhibitors. Although CCNE1 amplification is generally mutually exclusive with BRCA mutations, CCNE1 overexpression parado...

Xue-Ling Wang, Tian Chen, Ze-Hua Wang et al. · 0 citations

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