Open access
Sep 2026
Splicing modulation as an emerging therapeutic strategy in cancer: molecular mechanisms, clinical development, and future perspectives.
Progress will require more selective splicing-directed modalities, pharmacodynamic biomarkers that measure splicing perturbation in the relevant tumor or blood compartment, longitudinal mapping of genetic and tumor cell-state plasticity-driven resistance, and biomarker-defined combination trials to support expansion fr...
Xinbate Jingele, Qinxinru Sun, Xiao-Yang Li et al.
· Japanese Journal of Clinical... · 0 citations